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The effect of sodium nitrite, amyl nitrite and nitroglycerin glyceryl trinitrate on the hemoglobin of adult erythrocytes was examined in vitro. Both amyl nitrite and nitroglycerin reacted immediately with oxyhemoglobin to effect oxidation into methemoglobin while sodium nitrite required an inductionary period lag phase prior to the reaction. Kinetic studies of the biomolecular rate law for each of the preceding reaction's reactionary periods log phases allowed rate constant calculations to be made. The values are 1. A comparison of the amyl nitrite and nitroglycerin rate constants reveals that amyl nitrite is approximately fold more toxic to oxyhemoglobin than nitroglycerin.
These oxidant's effect Making amyl nitrate in vitro hemoglobin solutions are comparable since both reactions approximate to rectangular hyperbolae. Sodium nitrite reacts about fold faster with oxyhemoglobin than does nitroglycerin. However, the sodium nitrite reaction proceeds in a sigmoidal fashion which Making amyl nitrate a strict comparison between these compounds relative toxicities less clear cut. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.
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of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Cite Display options Display options. Abstract The effect of sodium nitrite, amyl nitrite and nitroglycerin glyceryl trinitrate on the hemoglobin of adult erythrocytes was examined in vitro. Making amyl nitrate articles Kinetics of amyl nitrite-induced hemoglobin oxidation in cord and adult blood. Tarburton JP, et al. PMID: Glutathione oxidation under the action of sodium nitrite on hemoglobin. Stepuro I, et al.
Pol J Pharmacol. Comparative effects of Making amyl nitrate trinitrate and amyl nitrite on pulse wave reflection and augmentation index. Greig LD, et al. Br J Clin Pharmacol. Clinical Trial. Does amyl nitrite have a role in the management of pre-hospital mass casualty cyanide poisoning? Lavon O, Bentur Y. Lavon O, et al. Clin Toxicol Phila. PMID: Review. Organic nitrates in angina pectoris. Bogaert MG. Arch Int Pharmacodyn Ther. No abstract available. See all similar articles. Cited by 1 article Drug-induced methaemoglobinaemia.
Treatment issues. Coleman MD, et al. Drug Saf. Publication types Comparative Study Actions. Humans Actions. Kinetics Actions. Oxidation-Reduction Actions. Substances Hemoglobins Actions. Nitrates Actions. Oxyhemoglobins Actions.
Pentanols Actions. Methemoglobin Actions. Nitroglycerin Actions. Copy Download.Making amyl nitrate
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The kinetic differences between sodium nitrite, amyl nitrite and nitroglycerin oxidation of hemoglobin