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Scarlet body and Ivory cap capsules. Amoxillin capsules is indicated for the treatment of the following infections in Max 500 tablet and children see sections 4. Consideration should be given to official guidance on the appropriate use of antibacterial agents. The dose of Amoxicillin that is selected to treat an individual infection should take into :. Some infections require longer periods of treatment see section 4. Children weighing 40 kg or more should Max 500 tablet prescribed the adult dosage. Recommended doses:. Prior to haemodialysis one additional dose of mg should be administered.
In order to restore circulating drug levels, another dose of mg should be administered after haemodialysis. Hypersensitivity to the active substance, to any of the penicillins or to any of the excipients listed in section 6. History of a severe immediate hypersensitivity reaction e. Before initiating therapy with amoxicillin, careful enquiry should be made concerning hypersensitivity reactions to penicillins, cephalosporins or other beta-lactam agencts see sections 4.
Serious and occasionally fatal hypersensitivity reactions including anaphylactoid and severe cutaneous adverse reactions have been reported in patients on penicillin therapy. These reactions are more likely to occur in individuals with a history of hypersensitivity and in atopic Max 500 tablet. If an allergic reaction occurs, amoxicillin therapy must be discontinued and appropriate alternative therapy instituted. Amoxicillin is not suitable for the treatment of some types of infection unless the pathogen is already documented and known to be susceptible or there is a very high likelihood that the pathogen would be suitable for treatment with amoxicillin see section 5.
This particularly applies when considering the treatment of patients with urinary tract infections and severe infections of the ear, nose and throat. Convulsions may occur in patients with impaired renal function or in those receiving high doses or in patients with predisposing factors e.
In patients with renal impairment, the rate of excretion of amoxicillin will be reduced depending on the degree of impairment and it may be necessary to reduce the total daily unit amoxicillin dosage accordingly see section 4. The occurrence at the treatment initiation of a feverish generalised erythema associated with pustula may be a symptom of acute generalised exanthemous pustulosis AEGP, see section 4. This reaction requires amoxicillin discontinuation and contra-indicates any subsequent administration.
Amoxicillin should be avoided if infectious mononucleosis is suspected since the occurrence of a morbilliform rash has been associated with this condition following the use of amoxicillin. The Jarisch-Herxheimer reaction has been seen following amoxicillin treatment of Lyme disease see section 4.
It directly from the bactericidal activity of amoxicillin on the causative bacteria of Lyme disease, the spirochaete Borrelia burgdorferi. Patients should be reassured that this is a common and usually self-limiting consequence of antibiotic treatment of Lyme disease. Prolonged use may also occasionally result in overgrowth of non-susceptible organisms. Antibiotic-associated colitis has been reported with nearly all antibacterial agents and may range in severity from mild to life threatening see section 4.
Therefore, it is important to consider this diagnosis in patients who present with diarrhoea during, or subsequent to, the administration of any antibiotics. Should antibiotic-associated colitis occur, amoxicillin should immediately be discontinued, a physician consulted and an appropriate therapy initiated. Anti-peristaltic medicinal products are contra-indicated in this situation. Periodic assessment of organ system functions; including renal, hepatic and Max 500 tablet function is advisable during prolonged therapy.
Elevated liver enzymes and changes in blood counts have been reported see section 4. Prolongation of prothrombin time has been reported rarely in patients receiving amoxicillin. Appropriate monitoring should Max 500 tablet undertaken when anticoagulants are prescribed concomitantly. Adjustments in the dose of Max 500 tablet anticoagulants may be necessary to maintain the desired level of anticoagulation see section 4.
In patients with reduced urine output, crystalluria has been observed very rarely, predominantly with parenteral therapy. During the administration of high doses of amoxicillin, it is advisable to maintain adequate fluid intake and urinary output in order to reduce the possibility of amoxicillin crystalluria. In patients with bladder catheters, a regular check of patency should be maintained see section 4. Elevated serum and urinary levels of amoxicillin are likely to affect certain laboratory tests. Due to the high urinary concentrations of amoxicillin, false positive readings are common with chemical methods.
It is recommended that when testing for the presence of glucose in urine during amoxicillin treatment, enzymatic glucose oxidase methods should be used. Concomitant use of probenecid is not recommended. Probenecid decreases the renal tubular secretion of amoxicillin. Concomitant use of probenecid may result in increased and prolonged blood levels of amoxicillin. Concurrent administration of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions.
Tetracyclines and other bacteriostatic drugs may interfere with the bactericidal effects of amoxicillin. Oral anticoagulants and penicillin antibiotics have been widely used in practice without reports of interaction.
However, in the literature there are cases of Max 500 tablet international normalised ratio in patients maintained on acenocoumarol or warfarin and prescribed a course of amoxicillin. If co-administration is necessary, the prothrombin time or international normalised ratio should be carefully monitored with the addition or withdrawal of amoxicillin.
Moreover, adjustments in the dose of oral anticoagulants may be necessary see sections 4. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity.
Limited data on the use of amoxicillin during pregnancy in humans do not indicate an increased risk of congenital malformations. Amoxicillin may be used in pregnancy when the potential benefits outweigh the potential risks associated with treatment.
Amoxicillin is excreted into breast milk in small quantities with the possible risk of sensitisation. Consequently, diarrhoea and fungus infection of the mucous membranes are possible in the breast-fed infant, so that breast-feeding might have to be discontinued. There are no data on the effects of amoxicillin on fertility in humans. Reproductive studies in animals have shown no effects on fertility. No studies on the effects on the ability to drive and use machines have been performed. However, undesirable effects may occur e.
The following terminologies have been used in order to classify the occurrence of undesirable effects. Infections and infestations. Reversible leucopenia including severe neutropenia or agranulocytosisreversible thrombocytopenia and haemolytic anaemia. Prolongation of bleeding time and prothrombin time see section 4. Severe allergic reactions, including angioneurotic oedema, anaphylaxis, serum sickness and hypersensitivity vasculitis see section 4. Antibiotic associated colitis including pseudomembraneous colitis and haemorrhagic colitis see section 4.
Skin reactions such as erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous and exfoliative dermatitis, acute generalized exanthematous pustulosis Max 500 tablet See section 4. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme.
Gastrointestinal symptoms such as nausea, vomiting and diarrhoea and disturbance of the fluid and electrolyte balances may be evident. Amoxicillin crystalluria, in some cases leading to renal failure, has been observed. Convulsions may occur in patients with impaired renal function or in those receiving high doses see sections 4.
Amoxicillin is a semisynthetic penicillin beta-lactam antibiotic that inhibits one or more enzymes often referred to as penicillin-binding proteins, PBPs in the biosynthetic pathway Max 500 tablet bacterial peptidoglycan, which is an integral structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis le to weakening of the cell wall, which is usually followed by cell lysis and death. Amoxicillin is susceptible to degradation by beta-lactamases produced by resistant bacteria and therefore the spectrum of activity of amoxicillin alone does not include organisms which produce these enzymes.
Impermeability of bacteria or efflux pump mechanisms may cause or contribute to bacterial resistance, particularly in Gram-negative bacteria. Some countries prefer to categorise wild type isolates of E. Methicillin resistant isolates are, with few exceptions, resistant to all beta-lactam agents. For isolates categorised as intermediate to ampicillin avoid oral treatment with amoxicillin.
Susceptibility inferred from the MIC of ampicillin. Beta-lactamase positive isolates should be reported resistant. The prevalence of resistance may vary geographically and with time for selected species, and local information on resistance is desirable, particularly when treating severe infections. As Max 500 tablet, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable. In vitro susceptibility of micro-organisms to Amoxicillin.
In addition, all methicillin-resistant strains are resistant to amoxicillin. Amoxicillin fully dissociates in aqueous Max 500 tablet at physiological pH. It is rapidly and well absorbed by the oral route of administration. The time to peak plasma concentration T max is approximately one hour.Max 500 tablet
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Amoxicillin mg Capsules BP