Added: Shakera Galgano - Date: 29.03.2022 16:04 - Views: 49242 - Clicks: 6529
Rationale: There is some uncertainty whether the acute hyperthermia caused by MDMA ecstasy plays a ificant role in determining the long-term neurotoxic effects on brain 5-HT systems and associated changes in mood and behaviour.
Objective: The present study assessed whether long-term behavioural and cognitive changes seen in MDMA-treated rats are affected by hyperthermia at the time of drug administration. Eight to 18 weeks later, rats were tested in behavioural measures of anxiety social interaction and emergence testsa test of cognition object recognition test Mdma side effects depression the forced swim test of depression. At the conclusion of behavioural testing the rats were killed and their brains analysed using HPLC.
Months later, rats pre-treated with MDMA at either 16 or 28 degrees C displayed increased anxiety in the social interaction and emergence tests and reduced escape attempts and increased immobility in the forced swim test. MDMA pre-treatment was also associated with poorer memory on the object recognition test, but only in rats given the drug at 28 degrees C.
Rats pre-treated with MDMA showed loss of 5-HT in the hippocampus, striatum, amygdala and cortex, regardless of body temperature at the time of dosing. However, 5-HIAA loss in the Mdma side effects depression and hippocampus was greater in rats pre-treated at 28 degrees C. Dopamine in the striatum was also depleted in rats given MDMA. Conclusions: These indicate that hyperthermia at the time of dosing with MDMA is not necessary to produce subsequent 5-HT depletion and anxiety in rats. They also extend findings of long-term effects of brief exposure to MDMA in rats to include apparent "depressive" symptoms in the forced swim model.
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Interpersonal Relations Actions. Male Actions. Medical Futility Actions. Rats Actions. Rats, Wistar Actions. Time Factors Actions. Substances Biogenic Monoamines Actions. N-Methyl-3,4-methylenedioxyamphetamine Actions. Full text links [x] Springer. Copy Download.Mdma side effects depression
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Ecstasy use triggers deep depression